Compounding Vitamin Capsules

Calculate adjustment factor for Vitamin raw ingredient.

Use the Certificate of Analysis (CofA) to calculate the adjustment factor for that batch. For example, the CofA below shows that Vitamin D3 powder contains 105,510IU/g.

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Work out the ratio between IU and G:

1/105,510 = 0.000009477 x 1000 = 0.009477 <- This is the adjustment factor to enter in your stock card.

 Create a new batch that contains the batch number and the calculated adjustment factor in the batch description. This will ensure the correct batch is selected when used in formulations; since the adjustment factors may vary between batches. Enter adjustment factor in stock card.

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Create Vitamin capsules formulation

Example: prescription for Vitamin D3 50,000IU, 100 capsules.

Enter the strength required in the Strength column in formulation screen. RxOne will calculate the amount of raw powder required to make 100 capsules using Adjustment factor: Strength 50,000mg = 50,000g. Weight = 50,000g x 0.009477 x 100 caps = 47.385g <- this is the amount of raw Vitamin D3 powder needed to make 100 capsules of Vitamin D3 50,000IU.

Notes:

If the total weight of all raw ingredients is larger than the amount of powder one capsule can hold, the total vitamin daily dose may need to be split into multiple capsules.

For example, prescription for Vitamin D3 50,000Iu one capsule daily, give 100 capsules. If the total weight of all ingredients is more than one capsule can hold, need to split the daily dose to 2 capsules daily. In this situation, you will need to create a formulation for Vitamin D3 25,000IU capsules and make 200 capsules, the instructions to patient will be 2 capsules daily to get 50,000IU.